Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations

Nine compounds (MO1–MO9) containing the morpholine moiety were assessed for their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Most of the compounds potently inhibited MAO-B; MO1 most potently inhibited with an IC(50) value of 0.030 µM, followed by MO7 (0....

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Detalles Bibliográficos
Autores principales: Sasidharan, Rani, Eom, Bo Hyun, Heo, Jeong Hyun, Park, Jong Eun, Abdelgawad, Mohamed A., Musa, Arafa, Gambacorta, Nicola, Nicolotti, Orazio, Manju, Sreedharannair Leelabaiamma, Mathew, Bijo, Kim, Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808749/
https://www.ncbi.nlm.nih.gov/pubmed/33430657
http://dx.doi.org/10.1080/14756366.2020.1842390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808749/
https://www.ncbi.nlm.nih.gov/pubmed/33430657
http://dx.doi.org/10.1080/14756366.2020.1842390

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