Inhibition of succinate dehydrogenase activity impairs human T cell activation and function

T cell activation is intimately linked to metabolism, as distinct metabolic requirements support the functional and phenotypical differences between quiescent and activated T cells. Metabolic transition from mitochondrial oxidative phosphorylation to aerobic glycolysis is crucial for a proper T cell...

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Detalles Bibliográficos
Autores principales: Nastasi, Claudia, Willerlev-Olsen, Andreas, Dalhoff, Kristoffer, Ford, Shayne L., Gadsbøll, Anne-Sofie Østergaard, Buus, Terkild Brink, Gluud, Maria, Danielsen, Morten, Litman, Thomas, Bonefeld, Charlotte Mennè, Geisler, Carsten, Ødum, Niels, Woetmann, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809054/
https://www.ncbi.nlm.nih.gov/pubmed/33446766
http://dx.doi.org/10.1038/s41598-020-80933-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809054/
https://www.ncbi.nlm.nih.gov/pubmed/33446766
http://dx.doi.org/10.1038/s41598-020-80933-7

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