Cargando…

Inhibition of succinate dehydrogenase activity impairs human T cell activation and function

T cell activation is intimately linked to metabolism, as distinct metabolic requirements support the functional and phenotypical differences between quiescent and activated T cells. Metabolic transition from mitochondrial oxidative phosphorylation to aerobic glycolysis is crucial for a proper T cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nastasi, Claudia, Willerlev-Olsen, Andreas, Dalhoff, Kristoffer, Ford, Shayne L., Gadsbøll, Anne-Sofie Østergaard, Buus, Terkild Brink, Gluud, Maria, Danielsen, Morten, Litman, Thomas, Bonefeld, Charlotte Mennè, Geisler, Carsten, Ødum, Niels, Woetmann, Anders
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809054/ https://www.ncbi.nlm.nih.gov/pubmed/33446766 http://dx.doi.org/10.1038/s41598-020-80933-7

Ejemplares similares

Publisher Correction: Inhibition of succinate dehydrogenase activity impairs human T cell activation and function
por: Nastasi, Claudia, et al.
Publicado: (2021)

In vitro differentiated human CD4(+) T cells produce hepatocyte growth factor
por: Ford, Shayne Lavondua, et al.
Publicado: (2023)

Increased Production of IL-17A-Producing γδ T Cells in the Thymus of Filaggrin-Deficient Mice
por: Jee, Mia Hamilton, et al.
Publicado: (2018)

Development of interleukin-17-producing Vγ2(+) γδ T cells is reduced by ICOS signaling in the thymus
por: Buus, Terkild Brink, et al.
Publicado: (2016)

Butyrate and propionate inhibit antigen-specific CD8(+) T cell activation by suppressing IL-12 production by antigen-presenting cells
por: Nastasi, Claudia, et al.
Publicado: (2017)

The effect of short-chain fatty acids on human monocyte-derived dendritic cells
por: Nastasi, Claudia, et al.
Publicado: (2015)

Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4(+) T cells in cutaneous T-cell lymphoma
por: Blümel, Edda, et al.
Publicado: (2019)

MicroRNAs in the Pathogenesis, Diagnosis, Prognosis and Targeted Treatment of Cutaneous T-Cell Lymphomas
por: Gluud, Maria, et al.
Publicado: (2020)

Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus
por: Buus, Terkild Brink, et al.
Publicado: (2017)

Staphylococcus aureus enterotoxins induce FOXP3 in neoplastic T cells in Sézary syndrome
por: Willerslev-Olsen, Andreas, et al.
Publicado: (2020)

Staphylococcus aureus alpha-toxin inhibits CD8(+) T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma
por: Blümel, Edda, et al.
Publicado: (2020)

JAK3 Is Expressed in the Nucleus of Malignant T Cells in Cutaneous T Cell Lymphoma (CTCL)
por: Vadivel, Chella Krishna, et al.
Publicado: (2021)

Activated human CD4(+) T cells express transporters for both cysteine and cystine
por: Levring, Trine Bøegh, et al.
Publicado: (2012)

Human CD4(+) T cells require exogenous cystine for glutathione and DNA synthesis
por: Levring, Trine B., et al.
Publicado: (2015)

Vitamin D-binding protein controls T cell responses to vitamin D
por: Kongsbak, Martin, et al.
Publicado: (2014)

Macrophages Control the Bioavailability of Vitamin D and Vitamin D-Regulated T Cell Responses
por: Lopez, Daniel Villalba, et al.
Publicado: (2021)

Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
por: Rode, Anna K. O., et al.
Publicado: (2022)

NKG2D-dependent activation of dendritic epidermal T cells in contact hypersensitivity
por: Nielsen, Morten Milek, et al.
Publicado: (2015)

Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome
por: Hu, Tengpeng, et al.
Publicado: (2019)

MicroRNA-106b Regulates Expression of the Tumour Suppressors p21 and TXNIP and Promotes Tumour Cell Proliferation in Mycosis Fungoides
por: LINDAHL, Lise M., et al.
Publicado: (2020)

Impaired Vitamin D Signaling in T Cells From a Family With Hereditary Vitamin D Resistant Rickets
por: Al-Jaberi, Fatima A. H., et al.
Publicado: (2021)

Normal T and B Cell Responses Against SARS-CoV-2 in a Family With a Non-Functional Vitamin D Receptor: A Case Report
por: Kongsbak-Wismann, Martin, et al.
Publicado: (2021)

Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin
por: Woetmann, Anders, et al.
Publicado: (2018)

Malignant T cells activate endothelial cells via IL-17 F
por: Lauenborg, B, et al.
Publicado: (2017)

Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma
por: Stolearenco, Veronica, et al.
Publicado: (2020)

Bacterial Toxins Fuel Disease Progression in Cutaneous T-Cell Lymphoma
por: Willerslev-Olsen, Andreas, et al.
Publicado: (2013)

Succinic Dehydrogenase and Cytochrome Oxidase Activities in Cell Cultures
por: Leslie, I., et al.
Publicado: (1960)

Effect of Salt Stress on the Activity, Expression, and Promoter Methylation of Succinate Dehydrogenase and Succinic Semialdehyde Dehydrogenase in Maize (Zea mays L.) Leaves
por: Fedorin, Dmitry N., et al.
Publicado: (2022)

Succinate dehydrogenase‐deficient malignant paraganglioma complicated by succinate dehydrogenase‐deficient renal cell carcinoma
por: Yamaguchi, Yoshitomo, et al.
Publicado: (2022)

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity
por: Finley, Lydia W. S., et al.
Publicado: (2011)

A spectrophotometric coupled enzyme assay to measure the activity of succinate dehydrogenase()
por: Jones, Andrew J.Y., et al.
Publicado: (2013)

Ectopic expression of a novel CD22 splice-variant regulates survival and proliferation in malignant T cells from cutaneous T cell lymphoma (CTCL) patients
por: Bagdonaite, Ieva, et al.
Publicado: (2015)

Succinate dehydrogenase expression in breast cancer
por: Kim, Sewha, et al.
Publicado: (2013)

Succinic Semialdehyde Dehydrogenase Deficiency: An Update
por: Didiasova, Miroslava, et al.
Publicado: (2020)

Midline 1 controls polarization and migration of murine cytotoxic T cells
por: Boding, Lasse, et al.
Publicado: (2014)

A TISSUE FACTOR INFLUENCING SUCCINIC DEHYDROGENASE ACTIVITY IN TUBERCULOUS GUINEA PIGS
por: Martin, S. P., et al.
Publicado: (1955)

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism
por: Lussey-Lepoutre, Charlotte, et al.
Publicado: (2015)

The mitochondrial LYR protein SDHAF1 is required for succinate dehydrogenase activity in Arabidopsis
por: Li, Ying, et al.
Publicado: (2022)

Discovery of novel pyridine carboxamides with antifungal activity as potential succinate dehydrogenase inhibitors
por: Yan, Zhongzhong, et al.
Publicado: (2022)

Dendritic Epidermal T Cells in Allergic Contact Dermatitis
por: Mraz, Veronika, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2ppo087cqgbuqqkhdt931c0c0h