Bone tumor–targeted delivery of theranostic (195m)Pt-bisphosphonate complexes promotes killing of metastatic tumor cells

Platinum-based drugs such as cisplatin are very potent chemotherapeutics, whereas radioactive platinum ((195m)Pt) is a rich source of low-energy Auger electrons, which kills tumor cells by damaging DNA. Auger electrons damage cells over a very short range. Consequently, (195m)Pt-based radiopharmaceu...

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Detalles Bibliográficos
Autores principales: Nadar, R.A., Franssen, G.M., Van Dijk, N.W.M., Codee-van der Schilden, K., de Weijert, M., Oosterwijk, E., Iafisco, M., Margiotta, N., Heskamp, S., van den Beucken, J.J.J.P., Leeuwenburgh, S.C.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809194/
https://www.ncbi.nlm.nih.gov/pubmed/33490949
http://dx.doi.org/10.1016/j.mtbio.2020.100088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809194/
https://www.ncbi.nlm.nih.gov/pubmed/33490949
http://dx.doi.org/10.1016/j.mtbio.2020.100088

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