Progranulin depletion inhibits proliferation via the transforming growth factor beta/SMAD family member 2 signaling axis in Kasumi-1 cells

Progranulin is an autocrine growth factor that promotes proliferation, migration, invasion, and chemoresistance of various cancer cells. These mechanisms mainly depend on the protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) pathway. Recent studies have shown that patients with hematopoi...

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Detalles Bibliográficos
Autores principales: Yabe, Kuniaki, Yamamoto, Yasuko, Takemura, Masao, Hara, Takeshi, Tsurumi, Hisashi, Serrero, Ginette, Nabeshima, Toshitaka, Saito, Kuniaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809376/
https://www.ncbi.nlm.nih.gov/pubmed/33490663
http://dx.doi.org/10.1016/j.heliyon.2020.e05849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809376/
https://www.ncbi.nlm.nih.gov/pubmed/33490663
http://dx.doi.org/10.1016/j.heliyon.2020.e05849

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