A disease-causing mutation K240E disrupts ferroportin trafficking by SUMO (ferroportin SUMOylation)

Ferroportin (Fpn/IREG1/MTP1) is the only known transporter mediating iron efflux from epithelial cells and macrophages, and thus regulates how much iron is released into the circulation. Consequently, Fpn mutations are associated with haemochromatosis. Fpn itself is post-translationally regulated by...

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Detalles Bibliográficos
Autores principales: Bayele, Henry K., Srai, Surjit Kaila S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809393/
https://www.ncbi.nlm.nih.gov/pubmed/33490642
http://dx.doi.org/10.1016/j.bbrep.2020.100873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809393/
https://www.ncbi.nlm.nih.gov/pubmed/33490642
http://dx.doi.org/10.1016/j.bbrep.2020.100873

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