Effect of 5-HT2A receptor antagonism on levels of D2/3 receptor occupancy and adverse behavioral side-effects induced by haloperidol: a SPECT imaging study in the rat

Several studies suggested that 5-HT(2A) receptor (5-HT(2A)R) blockade may provide a more favorable efficacy and side-effect profile to antipsychotic treatment. We hypothesized that a combined haloperidol (a D(2/3) receptor (D(2/3)R) antagonist) and MDL-100,907 (a 5-HT(2A)R antagonist) treatment woul...

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Detalles Bibliográficos
Autores principales: Tsartsalis, Stergios, Tournier, Benjamin B., Gloria, Yesica, Millet, Philippe, Ginovart, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809418/
https://www.ncbi.nlm.nih.gov/pubmed/33446643
http://dx.doi.org/10.1038/s41398-020-01179-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809418/
https://www.ncbi.nlm.nih.gov/pubmed/33446643
http://dx.doi.org/10.1038/s41398-020-01179-5

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