TCF7L2 silencing results in altered gene expression patterns accompanied by local genomic reorganization

Canonical Wnt signaling is crucial for intestinal homeostasis as TCF4, the major Wnt signaling effector in the intestines, is required for stem cell maintenance. The capability of TCF4 to maintain the stem cell phenotype is contingent upon β-catenin, a potent transcriptional activator, which interac...

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Detalles Bibliográficos
Autores principales: Brown, Markus A., Dotson, Gabrielle A., Ronquist, Scott, Emons, Georg, Rajapakse, Indika, Ried, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809436/
https://www.ncbi.nlm.nih.gov/pubmed/33422939
http://dx.doi.org/10.1016/j.neo.2020.12.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809436/
https://www.ncbi.nlm.nih.gov/pubmed/33422939
http://dx.doi.org/10.1016/j.neo.2020.12.010

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