A negative feedback loop maintains optimal chemokine concentrations for directional cell migration

Chemoattractant gradients often guide migrating cells. To achieve the greatest directional signal over noise, such gradients should be maintained with concentrations around the chemoreceptor’s dissociation constant (K(d)) (1–6). Whether this is true in animals is unknown. Here, we investigate whethe...

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Detalles Bibliográficos
Autores principales: Lau, Stephanie, Feitzinger, Anna, Venkiteswaran, Gayatri, Wang, John, Lewellis, Stephen W., Koplinski, Chad A., Peterson, Francis C., Volkman, Brian F., Meier-Schellersheim, Martin, Knaut, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809593/
https://www.ncbi.nlm.nih.gov/pubmed/32042179
http://dx.doi.org/10.1038/s41556-020-0465-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809593/
https://www.ncbi.nlm.nih.gov/pubmed/32042179
http://dx.doi.org/10.1038/s41556-020-0465-4

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