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Sequence and Structure-Based Analysis of Specificity Determinants in Eukaryotic Protein Kinases
Protein kinases lie at the heart of cell-signaling processes and are often mutated in disease. Kinase target recognition at the active site is in part determined by a few amino acids around the phosphoacceptor residue. However, relatively little is known about how most preferences are encoded in the...
Autores principales: | Bradley, David, Viéitez, Cristina, Rajeeve, Vinothini, Selkrig, Joel, Cutillas, Pedro R., Beltrao, Pedro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809594/ https://www.ncbi.nlm.nih.gov/pubmed/33440154 http://dx.doi.org/10.1016/j.celrep.2020.108602 |
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