Familial Alzheimer’s Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

Mutations in presenilin 1 (PSEN1) or presenilin 2 (PSEN2), the catalytic subunit of γ-secretase, cause familial Alzheimer’s disease (fAD). We hypothesized that mutations in PSEN1 reduce Notch signaling and alter neurogenesis. Expression data from developmental and adult neurogenesis show relative en...

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Detalles Bibliográficos
Autores principales: Arber, Charles, Lovejoy, Christopher, Harris, Lachlan, Willumsen, Nanet, Alatza, Argyro, Casey, Jackie M., Lines, Georgie, Kerins, Caoimhe, Mueller, Anika K., Zetterberg, Henrik, Hardy, John, Ryan, Natalie S., Fox, Nick C., Lashley, Tammaryn, Wray, Selina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809623/
https://www.ncbi.nlm.nih.gov/pubmed/33440141
http://dx.doi.org/10.1016/j.celrep.2020.108615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809623/
https://www.ncbi.nlm.nih.gov/pubmed/33440141
http://dx.doi.org/10.1016/j.celrep.2020.108615

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