Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic β-Cells

A sustained increase in intracellular Ca(2+) concentration (referred to hereafter as excitotoxicity), brought on by chronic metabolic stress, may contribute to pancreatic β-cell failure. To determine the additive effects of excitotoxicity and overnutrition on β-cell function and gene expression, we...

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Detalles Bibliográficos
Autores principales: Osipovich, Anna B., Stancill, Jennifer S., Cartailler, Jean-Philippe, Dudek, Karrie D., Magnuson, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2020
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809715/
https://www.ncbi.nlm.nih.gov/pubmed/32332159
http://dx.doi.org/10.2337/db19-1145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809715/
https://www.ncbi.nlm.nih.gov/pubmed/32332159
http://dx.doi.org/10.2337/db19-1145

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