Cargando…

Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic β-Cells

A sustained increase in intracellular Ca(2+) concentration (referred to hereafter as excitotoxicity), brought on by chronic metabolic stress, may contribute to pancreatic β-cell failure. To determine the additive effects of excitotoxicity and overnutrition on β-cell function and gene expression, we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Osipovich, Anna B., Stancill, Jennifer S., Cartailler, Jean-Philippe, Dudek, Karrie D., Magnuson, Mark A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2020
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809715/ https://www.ncbi.nlm.nih.gov/pubmed/32332159 http://dx.doi.org/10.2337/db19-1145

Ejemplares similares

Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes
por: Stancill, Jennifer S., et al.
Publicado: (2017)

FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation
por: Li, Mingyu, et al.
Publicado: (2016)

The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function
por: Spaeth, Jason M., et al.
Publicado: (2019)

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion
por: Golson, Maria L., et al.
Publicado: (2015)

Insm1, Neurod1, and Pax6 promote murine pancreatic endocrine cell development through overlapping yet distinct RNA transcription and splicing programs
por: Dudek, Karrie D, et al.
Publicado: (2021)

Targeted Disruption of Pancreatic-Derived Factor (PANDER, FAM3B) Impairs Pancreatic β-Cell Function
por: Robert-Cooperman, Claudia E., et al.
Publicado: (2010)

Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion : A New Mechanism for Fat-Induced Impairment of β-Cell Function
por: Kebede, Melkam, et al.
Publicado: (2008)

Lipid Droplets Protect Human β-Cells From Lipotoxicity-Induced Stress and Cell Identity Changes
por: Tong, Xin, et al.
Publicado: (2021)

Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size
por: Gu, Yanyun, et al.
Publicado: (2011)

Convergence of the Insulin and Serotonin Programs in the Pancreatic β-Cell
por: Ohta, Yasuharu, et al.
Publicado: (2011)

Islet-1 Is Essential for Pancreatic β-Cell Function
por: Ediger, Benjamin N., et al.
Publicado: (2014)

Tshz1 Regulates Pancreatic β-Cell Maturation
por: Raum, Jeffrey C., et al.
Publicado: (2015)

Postnatal Expansion of the Pancreatic β-Cell Mass Is Dependent on Survivin
por: Jiang, Yuying, et al.
Publicado: (2008)

Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells
por: Kim, Wook, et al.
Publicado: (2011)

XPR1 Mediates the Pancreatic β-Cell Phosphate Flush
por: Barker, Christopher J., et al.
Publicado: (2021)

MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner
por: Artner, Isabella, et al.
Publicado: (2010)

ZFP92, a KRAB domain zinc finger protein enriched in pancreatic islets, binds to B1/Alu SINE transposable elements and regulates retroelements and genes
por: Osipovich, Anna B., et al.
Publicado: (2023)

ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation
por: Metukuri, Mallikarjuna R., et al.
Publicado: (2012)

Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass
por: Oh, Eunjin, et al.
Publicado: (2018)

Residual Insulin Production and Pancreatic β-Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study
por: Keenan, Hillary A., et al.
Publicado: (2010)

Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells
por: Hisanaga, Etsuko, et al.
Publicado: (2009)

Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells
por: Cullen, Kirsty S., et al.
Publicado: (2011)

A Role for von Hippel-Lindau Protein in Pancreatic β-Cell Function
por: Puri, Sapna, et al.
Publicado: (2009)

Conditional Gene Targeting in Mouse Pancreatic β-Cells: Analysis of Ectopic Cre Transgene Expression in the Brain
por: Wicksteed, Barton, et al.
Publicado: (2010)

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth
por: Hang, Yan, et al.
Publicado: (2014)

Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling
por: Sohn, Paul, et al.
Publicado: (2023)

γ-Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic β-Cells
por: Braun, Matthias, et al.
Publicado: (2010)

Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes
por: Matsuoka, Taka-aki, et al.
Publicado: (2010)

G(0)-G(1) Transition and the Restriction Point in Pancreatic β-Cells In Vivo
por: Hija, Ayat, et al.
Publicado: (2014)

Bcl-2 and Bcl-x(L) Suppress Glucose Signaling in Pancreatic β-Cells
por: Luciani, Dan S., et al.
Publicado: (2013)

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes
por: Dahan, Tehila, et al.
Publicado: (2017)

HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats
por: Maachi, Hasna, et al.
Publicado: (2020)

DNA Methylation–Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity
por: Parveen, Nazia, et al.
Publicado: (2023)

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9
por: Lenoir, Olivia, et al.
Publicado: (2011)

Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets
por: Kato, Toyonori, et al.
Publicado: (2008)

Loss of HGF/c-Met Signaling in Pancreatic β-Cells Leads to Incomplete Maternal β-Cell Adaptation and Gestational Diabetes Mellitus
por: Demirci, Cem, et al.
Publicado: (2012)

Deletion of Pten in Pancreatic β-Cells Protects Against Deficient β-Cell Mass and Function in Mouse Models of Type 2 Diabetes
por: Wang, Linyuan, et al.
Publicado: (2010)

Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction
por: Lovis, Pascal, et al.
Publicado: (2008)

Changes in MicroRNA Expression Contribute to Pancreatic β-Cell Dysfunction in Prediabetic NOD Mice
por: Roggli, Elodie, et al.
Publicado: (2012)

Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis
por: Kondo, Tatsuya, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_qgn5t8r805rnkdicsjm8j40dka