Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia

BACKGROUND: Exportin 1 (XPO1/CRM1) is a key mediator of nuclear export with relevance to multiple cancers, including chronic lymphocytic leukemia (CLL). Whole exome sequencing has identified hot-spot somatic XPO1 point mutations which we found to disrupt highly conserved biophysical interactions in...

Descripción completa

Detalles Bibliográficos
Autores principales: Walker, Janek S., Hing, Zachary A., Harrington, Bonnie, Baumhardt, Jordan, Ozer, Hatice Gulcin, Lehman, Amy, Giacopelli, Brian, Beaver, Larry, Williams, Katie, Skinner, Jordan N., Cempre, Casey B., Sun, Qingxiang, Shacham, Sharon, Stromberg, Benjamin R., Summers, Matthew K., Abruzzo, Lynne V., Rassenti, Laura, Kipps, Thomas J., Parikh, Sameer, Kay, Neil E., Rogers, Kerry A., Woyach, Jennifer A., Coppola, Vincenzo, Chook, Yuh Min, Oakes, Christopher, Byrd, John C., Lapalombella, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809770/
https://www.ncbi.nlm.nih.gov/pubmed/33451349
http://dx.doi.org/10.1186/s13045-021-01032-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809770/
https://www.ncbi.nlm.nih.gov/pubmed/33451349
http://dx.doi.org/10.1186/s13045-021-01032-2

Ejemplares similares