α-Synuclein Aggregates Increase the Conductance of Substantia Nigra Dopamine Neurons, an Effect Partly Reversed by the KATP Channel Inhibitor Glibenclamide

Dopaminergic neurons (DNs) in the substantia nigra pars compacta (SNpc) form an important part of the basal ganglia circuitry, playing key roles in movement initiation and coordination. A hallmark of Parkinson’s disease (PD) is the degeneration of these SNpc DNs leading to akinesia, bradykinesia and...

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Detalles Bibliográficos
Autores principales: Hill, E., Gowers, R., Richardson, M. J. E., Wall, M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810260/
https://www.ncbi.nlm.nih.gov/pubmed/33229413
http://dx.doi.org/10.1523/ENEURO.0330-20.2020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810260/
https://www.ncbi.nlm.nih.gov/pubmed/33229413
http://dx.doi.org/10.1523/ENEURO.0330-20.2020

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