Discovery of beta-lactamase CMY-10 inhibitors for combination therapy against multi-drug resistant Enterobacteriaceae

β-lactam antibiotics are the most widely used antimicrobial agents since the discovery of benzylpenicillin in the 1920s. Unfortunately, these life-saving antibiotics are vulnerable to inactivation by continuously evolving β-lactamase enzymes that are primary resistance determinants in multi-drug res...

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Detalles Bibliográficos
Autores principales: Parvaiz, Nousheen, Ahmad, Faisal, Yu, Wenbo, MacKerell, Alexander D., Azam, Syed Sikander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810305/
https://www.ncbi.nlm.nih.gov/pubmed/33449932
http://dx.doi.org/10.1371/journal.pone.0244967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810305/
https://www.ncbi.nlm.nih.gov/pubmed/33449932
http://dx.doi.org/10.1371/journal.pone.0244967

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