Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization

SMAC/DIABLO and HTRA2 are mitochondrial proteins whose amino-terminal sequences, known as inhibitor of apoptosis binding motifs (IBMs), bind and activate ubiquitin ligases known as inhibitor of apoptosis proteins (IAPs), unleashing a cell’s apoptotic potential. IBMs comprise a four-residue, loose co...

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Detalles Bibliográficos
Autores principales: Mueller, Franziska, Friese, Alexandra, Pathe, Claudio, da Silva, Richard Cardoso, Rodriguez, Kenny Bravo, Musacchio, Andrea, Bange, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810383/
https://www.ncbi.nlm.nih.gov/pubmed/33523899
http://dx.doi.org/10.1126/sciadv.abc8590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810383/
https://www.ncbi.nlm.nih.gov/pubmed/33523899
http://dx.doi.org/10.1126/sciadv.abc8590

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