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A method of purifying alpha-synuclein in E. coli without chromatography

Research has implicated alpha-synuclein (aSyn) in pathological protein aggregation observed in almost all patients with Parkinson's disease and more than 50% of patients with Alzheimer's disease. An easy and inexpensive method of purifying aSyn and developing an in vitro model system of Le...

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Detalles Bibliográficos
Autores principales: Kamboj, Sumaer, Harms, Chase, Kumar, Lokender, Creamer, Daniel, West, Colista, Klein-Seetharaman, Judith, Sarkar, Susanta K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810624/
https://www.ncbi.nlm.nih.gov/pubmed/33490665
http://dx.doi.org/10.1016/j.heliyon.2020.e05874