Inhibition of mitochondrial complex II in neuronal cells triggers unique pathways culminating in autophagy with implications for neurodegeneration

Mitochondrial dysfunction and neurodegeneration underlie movement disorders such as Parkinson’s disease, Huntington’s disease and Manganism among others. As a corollary, inhibition of mitochondrial complex I (CI) and complex II (CII) by toxins 1-methyl-4-phenylpyridinium (MPP(+)) and 3-nitropropioni...

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Detalles Bibliográficos
Autores principales: Ranganayaki, Sathyanarayanan, Jamshidi, Neema, Aiyaz, Mohamad, Rashmi, Santhosh-Kumar, Gayathri, Narayanappa, Harsha, Pulleri Kandi, Padmanabhan, Balasundaram, Srinivas Bharath, Muchukunte Mukunda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810707/
https://www.ncbi.nlm.nih.gov/pubmed/33452321
http://dx.doi.org/10.1038/s41598-020-79339-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810707/
https://www.ncbi.nlm.nih.gov/pubmed/33452321
http://dx.doi.org/10.1038/s41598-020-79339-2

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