EBF1 drives hallmark B cell gene expression by enabling the interaction of PAX5 with the MLL H3K4 methyltransferase complex

PAX5 and EBF1 work synergistically to regulate genes that are involved in B lymphocyte differentiation. We used the KIS-1 diffuse large B cell lymphoma cell line, which is reported to have elevated levels of PAX5 expression, to investigate the mechanism of EBF1- and PAX5-regulated gene expression. W...

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Detalles Bibliográficos
Autores principales: Bullerwell, Charles E., Robichaud, Philippe Pierre, Deprez, Pierre M. L., Joy, Andrew P., Wajnberg, Gabriel, D’Souza, Darwin, Chacko, Simi, Fournier, Sébastien, Crapoulet, Nicolas, Barnett, David A., Lewis, Stephen M., Ouellette, Rodney J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810865/
https://www.ncbi.nlm.nih.gov/pubmed/33452395
http://dx.doi.org/10.1038/s41598-021-81000-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810865/
https://www.ncbi.nlm.nih.gov/pubmed/33452395
http://dx.doi.org/10.1038/s41598-021-81000-5

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