Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis

Mycobacterium tuberculosis secretes the tuberculosis necrotizing toxin (TNT) to kill host cells. Here, we show that the WXG100 proteins EsxE and EsxF are essential for TNT secretion. EsxE and EsxF form a water-soluble heterodimer (EsxEF) that assembles into oligomers and long filaments, binds to mem...

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Detalles Bibliográficos
Autores principales: Tak, Uday, Dokland, Terje, Niederweis, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810871/
https://www.ncbi.nlm.nih.gov/pubmed/33452244
http://dx.doi.org/10.1038/s41467-020-20533-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810871/
https://www.ncbi.nlm.nih.gov/pubmed/33452244
http://dx.doi.org/10.1038/s41467-020-20533-1

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