Cargando…

Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model

Transgenic mouse models recapitulating Alzheimer’s disease (AD) pathology are pivotal in molecular studies and drug evaluation. In transgenic models selectively expressing amyloid-β (Aβ), thioflavin S (ThS), a fluorescent dye with β-sheet binding properties, is widely employed to observe amyloid pla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shin, Jisu, Park, Sohui, Lee, HeeYang, Kim, YoungSoo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7810901/ https://www.ncbi.nlm.nih.gov/pubmed/33452414 http://dx.doi.org/10.1038/s41598-021-81304-6

Ejemplares similares

Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer’s disease
por: Park, Sohui, et al.
Publicado: (2021)

Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model
por: Kim, DaWon, et al.
Publicado: (2020)

Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation
por: Xue, Christine, et al.
Publicado: (2017)

Correction: Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model
por: Kim, DaWon, et al.
Publicado: (2021)

Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation
por: Lee, Donghee, et al.
Publicado: (2023)

Exploring the occurrence of thioflavin-T-positive insulin amyloid aggregation intermediates
por: Ziaunys, Mantas, et al.
Publicado: (2021)

Laser Emission of Thioflavin T Uncovers Protein Aggregation in Amyloid Nucleation Phase
por: Hanczyc, Piotr, et al.
Publicado: (2021)

Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice
por: Houben, Sarah, et al.
Publicado: (2020)

Jowiseungchungtang Inhibits Amyloid-β Aggregation and Amyloid-β-Mediated Pathology in 5XFAD Mice
por: Shin, Soo Jung, et al.
Publicado: (2018)

Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer’s Disease
por: Stefanescu, Raluca, et al.
Publicado: (2020)

Inhalable Thioflavin S for the Detection of Amyloid Beta Deposits in the Retina
por: Barton, Shawn M., et al.
Publicado: (2021)

Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease
por: Govindarajan, Karthivashan, et al.
Publicado: (2023)

Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice
por: Bader, Angelika Sabine, et al.
Publicado: (2023)

Correction: Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease
por: Govindarajan, Karthivashan, et al.
Publicado: (2023)

Solid-phase synthesis and pathological evaluation of pyroglutamate amyloid-β(3-42) peptide
por: Cho, Illhwan, et al.
Publicado: (2023)

Analyzing Thioflavin T Binding to Amyloid Fibrils by an Equilibrium Microdialysis-Based Technique
por: Kuznetsova, Irina M., et al.
Publicado: (2012)

Investigation of α-Synuclein Amyloid Fibrils Using the Fluorescent Probe Thioflavin T
por: Sulatskaya, Anna I., et al.
Publicado: (2018)

Stoichiometry and Affinity of Thioflavin T Binding to Sup35p Amyloid Fibrils
por: Sulatskaya, Anna I., et al.
Publicado: (2016)

The effect of electroconvulsive therapy on neuroinflammation, behavior and amyloid plaques in the 5xFAD mouse model of Alzheimer’s disease
por: Svensson, Martina, et al.
Publicado: (2021)

Bicine promotes rapid formation of β-sheet-rich amyloid-β fibrils
por: Kim, Hye Yun, et al.
Publicado: (2020)

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease
por: Lee, Jiyeon, et al.
Publicado: (2019)

Fluorescence Quantum Yield of Thioflavin T in Rigid Isotropic Solution and Incorporated into the Amyloid Fibrils
por: Sulatskaya, Anna I., et al.
Publicado: (2010)

Polarized super-resolution structural imaging inside amyloid fibrils using Thioflavine T
por: Shaban, Haitham A., et al.
Publicado: (2017)

Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T
por: Yu, Lanlan, et al.
Publicado: (2020)

Effect of Ionic Strength on Thioflavin-T Affinity to Amyloid Fibrils and Its Fluorescence Intensity
por: Mikalauskaite, Kamile, et al.
Publicado: (2020)

Quantitation of Tissue Amyloid via Fluorescence Spectroscopy Using Controlled Concentrations of Thioflavin-S
por: MacKeigan, Tatiana P., et al.
Publicado: (2023)

Cyclopentanone Derivative Attenuates Memory Impairment by Inhibiting Amyloid Plaques Formation in the 5xFAD Mice
por: Ullah, Rahim, et al.
Publicado: (2021)

Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice
por: Delizannis, Argyro Thalia, et al.
Publicado: (2021)

4-Hydroxynonenal Immunoreactivity Is Increased in the Frontal Cortex of 5XFAD Transgenic Mice
por: Shin, Sang-Wook, et al.
Publicado: (2020)

Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease
por: Tsui, Ka Chun, et al.
Publicado: (2022)

Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice
por: Zhao, Peng, et al.
Publicado: (2022)

Alzheimer's Disease Diagnosis Using Misfolding Proteins in Blood
por: Lee, HeeYang, et al.
Publicado: (2020)

Tau’s Three-Repeat Domain and EFhd2 Co-incubation Leads to Increased Thioflavin Signal
por: Vega, Irving E., et al.
Publicado: (2018)

Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer’s Disease
por: Whitmore, Clayton A., et al.
Publicado: (2022)

Diagnosis of Alzheimer’s disease utilizing amyloid and tau as fluid biomarkers
por: Lee, Jinny Claire, et al.
Publicado: (2019)

Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model
por: Yang, Seung-Hoon, et al.
Publicado: (2015)

Thioflavin T fluoresces as excimer in highly concentrated aqueous solutions and as monomer being incorporated in amyloid fibrils
por: Sulatskaya, Anna I., et al.
Publicado: (2017)

Predicting Thioflavin Fluorescence of Retinal Amyloid Deposits Associated With Alzheimer's Disease from Their Polarimetric Properties
por: Qiu, Yunyi, et al.
Publicado: (2020)

Tau aggregation and its interplay with amyloid-β
por: Nisbet, Rebecca M., et al.
Publicado: (2014)

Small molecules to target tau amyloid aggregation
por: Manglano-Artuñedo, Zoe, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_57pgm901c99qej2phu7t57iup6