Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression

Promoter DNA methylation is a well-established mechanism of transcription repression, though its global correlation with gene expression is weak. This weak correlation can be attributed to the failure of current methylation quantification methods to consider the heterogeneity among sequenced bulk ce...

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Detalles Bibliográficos
Autores principales: Xu, Jianfeng, Shi, Jiejun, Cui, Xiaodong, Cui, Ya, Li, Jingyi Jessica, Goel, Ajay, Chen, Xi, Issa, Jean-Pierre, Su, Jianzhong, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811027/
https://www.ncbi.nlm.nih.gov/pubmed/33452255
http://dx.doi.org/10.1038/s41467-020-20492-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811027/
https://www.ncbi.nlm.nih.gov/pubmed/33452255
http://dx.doi.org/10.1038/s41467-020-20492-7

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