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Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression
Promoter DNA methylation is a well-established mechanism of transcription repression, though its global correlation with gene expression is weak. This weak correlation can be attributed to the failure of current methylation quantification methods to consider the heterogeneity among sequenced bulk ce...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811027/ https://www.ncbi.nlm.nih.gov/pubmed/33452255 http://dx.doi.org/10.1038/s41467-020-20492-7 |