Human neuronal signaling and communication assays to assess functional neurotoxicity

Prediction of drug toxicity on the human nervous system still relies mainly on animal experiments. Here, we developed an alternative system allowing assessment of complex signaling in both individual human neurons and on the network level. The LUHMES cultures used for our approach can be cultured in...

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Detalles Bibliográficos
Autores principales: Loser, Dominik, Schaefer, Jasmin, Danker, Timm, Möller, Clemens, Brüll, Markus, Suciu, Ilinca, Ückert, Anna-Katharina, Klima, Stefanie, Leist, Marcel, Kraushaar, Udo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811517/
https://www.ncbi.nlm.nih.gov/pubmed/33269408
http://dx.doi.org/10.1007/s00204-020-02956-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811517/
https://www.ncbi.nlm.nih.gov/pubmed/33269408
http://dx.doi.org/10.1007/s00204-020-02956-3

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