Cargando…

Interleukin‐6 neutralization ameliorates symptoms in prematurely aged mice

Hutchinson–Gilford progeria syndrome (HGPS) causes premature aging in children, with adipose tissue, skin and bone deterioration, and cardiovascular impairment. In HGPS cells and mouse models, high levels of interleukin‐6, an inflammatory cytokine linked to aging processes, have been detected. Here,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Squarzoni, Stefano, Schena, Elisa, Sabatelli, Patrizia, Mattioli, Elisabetta, Capanni, Cristina, Cenni, Vittoria, D'Apice, Maria Rosaria, Andrenacci, Davide, Sarli, Giuseppe, Pellegrino, Valeria, Festa, Anna, Baruffaldi, Fabio, Storci, Gianluca, Bonafè, Massimiliano, Barboni, Catia, Sanapo, Mara, Zaghini, Anna, Lattanzi, Giovanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811841/ https://www.ncbi.nlm.nih.gov/pubmed/33393189 http://dx.doi.org/10.1111/acel.13285

Ejemplares similares

Altered chromatin organization and SUN2 localization in mandibuloacral dysplasia are rescued by drug treatment
por: Camozzi, Daria, et al.
Publicado: (2012)

Familial partial lipodystrophy, mandibuloacral dysplasia and restrictive dermopathy feature barrier-to-autointegration factor (BAF) nuclear redistribution
por: Capanni, Cristina, et al.
Publicado: (2012)

Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin–BAF Interaction and BAF Nuclear Localization
por: Cenni, Vittoria, et al.
Publicado: (2020)

Diverse lamin-dependent mechanisms interact to control chromatin dynamics: Focus on laminopathies
por: Camozzi, Daria, et al.
Publicado: (2014)

Rapamycin treatment of Mandibuloacral Dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamics
por: Cenni, Vittoria, et al.
Publicado: (2014)

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype
por: Pellegrini, Camilla, et al.
Publicado: (2015)

Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria
por: Cenni, V., et al.
Publicado: (2011)

Erratum - Autophagic Degradation of Farnesylated Prelamin a as a Therapeutic Approach to Lamin-Linked Progeria
por: Cenni, V., et al.
Publicado: (2013)

PCAF Involvement in Lamin A/C-HDAC2 Interplay during the Early Phase of Muscle Differentiation
por: Santi, Spartaco, et al.
Publicado: (2020)

Tendon Extracellular Matrix Remodeling and Defective Cell Polarization in the Presence of Collagen VI Mutations
por: Antoniel, Manuela, et al.
Publicado: (2020)

Barrier-to-Autointegration Factor (BAF) involvement in prelamin A-related chromatin organization changes
por: Loi, Manuela, et al.
Publicado: (2015)

Lamins and bone disorders: current understanding and perspectives
por: Gargiuli, Chiara, et al.
Publicado: (2018)

αvβ3-integrin regulates PD-L1 expression and is involved in cancer immune evasion
por: Vannini, Andrea, et al.
Publicado: (2019)

Ankrd2 in Mechanotransduction and Oxidative Stress Response in Skeletal Muscle: New Cues for the Pathogenesis of Muscular Laminopathies
por: Cenni, Vittoria, et al.
Publicado: (2019)

Immunotherapeutic Efficacy of Retargeted oHSVs Designed for Propagation in an Ad Hoc Cell Line
por: Vannini, Andrea, et al.
Publicado: (2021)

Genotype of Immunologically Hot or Cold Tumors Determines the Antitumor Immune Response and Efficacy by Fully Virulent Retargeted oHSV
por: Gianni, Tatiana, et al.
Publicado: (2021)

Efficacy of Systemically Administered Retargeted Oncolytic Herpes Simplex Viruses—Clearance and Biodistribution in Naïve and HSV-Preimmune Mice
por: Vannini, Andrea, et al.
Publicado: (2023)

Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning
por: Pellegrini, Camilla, et al.
Publicado: (2019)

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C – Histone Deacetylase 2 Interaction in Human Cells
por: Mattioli, Elisabetta, et al.
Publicado: (2019)

The global health community must stand for health and democracy in Myanmar
por: Sarli, Leopoldo, et al.
Publicado: (2021)

A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors
por: Leoni, Valerio, et al.
Publicado: (2018)

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
por: Columbaro, M., et al.
Publicado: (2005)

The role of prelamin A post-translational maturation in stress response and 53BP1 recruitment
por: Capanni, Cristina, et al.
Publicado: (2022)

Different prelamin A forms accumulate in human fibroblasts: a study in experimental models and progeria
por: Dominici, S., et al.
Publicado: (2009)

Interprofessionalism and interprofessional research: a challenge still to be won in Italy
por: Sarli, Leopoldo, et al.
Publicado: (2019)

Ectopic Expression of Ankrd2 Affects Proliferation, Motility and Clonogenic Potential of Human Osteosarcoma Cells
por: Piazzi, Manuela, et al.
Publicado: (2021)

A realist synthesis of staff-based primary health care interventions addressing universal health coverage
por: D’Apice, Clelia, et al.
Publicado: (2022)

Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins
por: Evangelisti, Camilla, et al.
Publicado: (2015)

Myanmar health professionals’ educational needs: a pilot study
por: Mosca, Gloria, et al.
Publicado: (2020)

Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria‐related disorders
por: Evangelisti, Camilla, et al.
Publicado: (2016)

Towards a Precision Medicine Approach and In Situ Vaccination against Prostate Cancer by PSMA-Retargeted oHSV
por: Vannini, Andrea, et al.
Publicado: (2021)

Innovative retargeted oncolytic herpesvirus against nectin4-positive cancers
por: Vannini, Andrea, et al.
Publicado: (2023)

The VaRP Project: qualitative evaluation of the training effectiveness of Post Graduate Specializations for health professionals
por: Cosentino, Chiara, et al.
Publicado: (2020)

Gender and sex bias in prevention and clinical treatment of women’s chronic pain: hypotheses of a curriculum development
por: Moretti, Chiara, et al.
Publicado: (2023)

Early Morphological Changes of the Rectus Femoris Muscle and Deep Fascia in Ullrich Congenital Muscular Dystrophy
por: Sabatelli, Patrizia, et al.
Publicado: (2022)

Cutaneous and metabolic defects associated with nuclear abnormalities in a transgenic mouse model expressing R527H lamin A mutation causing mandibuloacral dysplasia type A (MADA) syndrome
por: D’Apice, Maria Rosaria, et al.
Publicado: (2020)

Silencing of Euchromatic Transposable Elements as a Consequence of Nuclear Lamina Dysfunction
por: Cavaliere, Valeria, et al.
Publicado: (2020)

From Genome-Wide to Environment-Wide: Capturing the Environome
por: von Stumm, Sophie, et al.
Publicado: (2021)

Novel mutations of TCOF1 gene in European patients with treacher Collins syndrome
por: Conte, Chiara, et al.
Publicado: (2011)

Molecular analysis using DHPLC of cystic fibrosis: increase of the mutation detection rate among the affected population in Central Italy
por: D'Apice, Maria Rosaria, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_osh0of7f875dlddb8h7826qi86