Effect of Kidney Function and Dialysis on the Pharmacokinetics and Pharmacodynamics of Roxadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor

BACKGROUND AND OBJECTIVES: Roxadustat is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor for anemia in chronic kidney disease. The pharmacokinetics, metabolic profile, and pharmacodynamics of roxadustat were investigated in subjects with different degrees of kidney function. M...

Descripción completa

Detalles Bibliográficos
Autores principales: Groenendaal-van de Meent, Dorien, Kerbusch, Virginie, Kaspera, Rudiger, Barroso-Fernandez, Begona, Galletti, Piergiorgio, Klein, Gernot K., den Adel, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811989/
https://www.ncbi.nlm.nih.gov/pubmed/33165773
http://dx.doi.org/10.1007/s13318-020-00658-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811989/
https://www.ncbi.nlm.nih.gov/pubmed/33165773
http://dx.doi.org/10.1007/s13318-020-00658-w

Ejemplares similares