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Effect of Kidney Function and Dialysis on the Pharmacokinetics and Pharmacodynamics of Roxadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor

BACKGROUND AND OBJECTIVES: Roxadustat is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor for anemia in chronic kidney disease. The pharmacokinetics, metabolic profile, and pharmacodynamics of roxadustat were investigated in subjects with different degrees of kidney function. M...

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Detalles Bibliográficos
Autores principales:	Groenendaal-van de Meent, Dorien, Kerbusch, Virginie, Kaspera, Rudiger, Barroso-Fernandez, Begona, Galletti, Piergiorgio, Klein, Gernot K., den Adel, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2020
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811989/ https://www.ncbi.nlm.nih.gov/pubmed/33165773 http://dx.doi.org/10.1007/s13318-020-00658-w

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