Salmonella Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages

Infection of human macrophages with Salmonella enterica serovar Typhimurium (S. Typhimurium) leads to inflammasome activation. Inflammasomes are multiprotein complexes facilitating caspase-1 activation and subsequent gasdermin D–mediated cell death and IL-1β and IL-18 cytokine release. The NAIP/NLRC...

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Detalles Bibliográficos
Autores principales: Gram, Anna M., Wright, John A., Pickering, Robert J., Lam, Nathaniel L., Booty, Lee M., Webster, Steve J., Bryant, Clare E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2021
Materias:
Innate Immunity and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812056/
https://www.ncbi.nlm.nih.gov/pubmed/33380493
http://dx.doi.org/10.4049/jimmunol.2000382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812056/
https://www.ncbi.nlm.nih.gov/pubmed/33380493
http://dx.doi.org/10.4049/jimmunol.2000382

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