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Ubiquitin‐specific protease 2 regulates Ang Ⅱ–induced cardiac fibroblasts activation by up‐regulating cyclin D1 and stabilizing β‐catenin in vitro

Cardiac fibrosis, featuring abnormally elevated extracellular matrix accumulation, decreases tissue compliance, impairs cardiac function and accelerates heart failure. Mounting evidence suggests that the ubiquitin proteasome pathway is involved in cardiac fibrosis. In the present study, ubiquitin‐sp...

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Detalles Bibliográficos
Autores principales: Xu, Qiong, Liu, Mingke, Zhang, Fangcheng, Liu, Xiaolin, Ling, Sisi, Chen, Xuke, Gu, Jielei, Ou, Wenchao, Liu, Shiming, Liu, Ningning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812274/
https://www.ncbi.nlm.nih.gov/pubmed/33314748
http://dx.doi.org/10.1111/jcmm.16162