Complement C5 activation promotes type 2 diabetic kidney disease via activating STAT3 pathway and disrupting the gut‐kidney axis

Diabetic kidney disease (DKD) is a severe DM complication. While complement C5 up‐regulation and gut dysbiosis are found in T2DM, their roles in DKD are unclear. Here, we investigated the effect of C5 on the gut microbiota during DKD development. Renal C5a/C5a receptor (C5aR) expression changes were...

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Detalles Bibliográficos
Autores principales: Li, Ling, Wei, Tiantian, Liu, Shuyun, Wang, Chengshi, Zhao, Meng, Feng, Yanhuan, Ma, Liang, Lu, Yanrong, Fu, Ping, Liu, Jingping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812276/
https://www.ncbi.nlm.nih.gov/pubmed/33280239
http://dx.doi.org/10.1111/jcmm.16157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812276/
https://www.ncbi.nlm.nih.gov/pubmed/33280239
http://dx.doi.org/10.1111/jcmm.16157

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