Cargando…

Complement C5 activation promotes type 2 diabetic kidney disease via activating STAT3 pathway and disrupting the gut‐kidney axis

Diabetic kidney disease (DKD) is a severe DM complication. While complement C5 up‐regulation and gut dysbiosis are found in T2DM, their roles in DKD are unclear. Here, we investigated the effect of C5 on the gut microbiota during DKD development. Renal C5a/C5a receptor (C5aR) expression changes were...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Ling, Wei, Tiantian, Liu, Shuyun, Wang, Chengshi, Zhao, Meng, Feng, Yanhuan, Ma, Liang, Lu, Yanrong, Fu, Ping, Liu, Jingping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812276/ https://www.ncbi.nlm.nih.gov/pubmed/33280239 http://dx.doi.org/10.1111/jcmm.16157

Ejemplares similares

Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance
por: Zhao, Meng, et al.
Publicado: (2021)

Indispensable role of mitochondria in maintaining the therapeutic potential of curcumin in acute kidney injury
por: Li, Ling, et al.
Publicado: (2021)

GLP-1 receptor agonist ameliorates obesity-induced chronic kidney injury via restoring renal metabolism homeostasis
por: Wang, Chengshi, et al.
Publicado: (2018)

Peritoneal M2 macrophage transplantation as a potential cell therapy for enhancing renal repair in acute kidney injury
por: Mao, Ruiwen, et al.
Publicado: (2020)

Control release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury
por: Zhao, Meng, et al.
Publicado: (2018)

Role of uromodulin and complement activation in the progression of kidney disease
por: Shen, Fei, et al.
Publicado: (2021)

Microbiome–metabolome reveals the contribution of gut–kidney axis on kidney disease
por: Chen, Yuan-Yuan, et al.
Publicado: (2019)

Complement Activation in Kidneys of Patients With COVID-19
por: Pfister, Frederick, et al.
Publicado: (2021)

Editorial: Role of complement activation in kidney diseases
por: Oda, Takashi, et al.
Publicado: (2023)

Causal relationship between kidney stones and gut microbiota contributes to the gut-kidney axis: a two-sample Mendelian randomization study
por: Liu, Minghui, et al.
Publicado: (2023)

Activation of complement system in kidney after ketoprofen-induced kidney injury in sheep
por: Palviainen, Mari J, et al.
Publicado: (2015)

Gut–Kidney Axis Investigations in Animal Models of Chronic Kidney Disease
por: Bartochowski, Piotr, et al.
Publicado: (2022)

Focus on the Gut–Kidney Axis in Health and Disease
por: Stavropoulou, Elisavet, et al.
Publicado: (2021)

Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury
por: Zhu, Lingling, et al.
Publicado: (2020)

The Intestinal Microbiota and Metabolites in the Gut-Kidney-Heart Axis of Chronic Kidney Disease
por: Huang, Yinghui, et al.
Publicado: (2022)

Complement in Kidney Transplantation
por: Cernoch, Marek, et al.
Publicado: (2017)

Understanding the Gut-Kidney Axis in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: An Analysis of Gut Microbiota Composition
por: Yu, Meilian, et al.
Publicado: (2022)

Association between serum complements and kidney function in patients with diabetic kidney disease
por: Liu, Meng-chao, et al.
Publicado: (2023)

The role of complement activation in rhabdomyolysis-induced acute kidney injury
por: Huang, XuDong, et al.
Publicado: (2018)

Potential Involvement of Complement Activation in Kidney Vascular Lesions of Arterionephrosclerosis
por: Chen, Xuejing, et al.
Publicado: (2022)

Commentary: Focus on the Gut–Kidney Axis in Health and Disease
por: Li, Yulu, et al.
Publicado: (2021)

Editorial: The gut-kidney axis: A potential drug target for treating kidney diseases
por: Chen, Jianping, et al.
Publicado: (2022)

Exploring a Complex Interplay: Kidney–Gut Axis in Pediatric Chronic Kidney Disease
por: Mocanu, Adriana, et al.
Publicado: (2023)

Molecular mechanisms and physiological functions of autophagy in kidney diseases
por: Yang, Jingchao, et al.
Publicado: (2022)

Bibliometric visualization analysis of gut-kidney axis from 2003 to 2022
por: Ai, Sinan, et al.
Publicado: (2023)

Leonurine-Repressed miR-18a-5p/SOCS5/JAK2/STAT3 Axis Activity Disrupts CML malignancy
por: Liu, Hui-Min, et al.
Publicado: (2021)

Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease
por: Hao, Wenyan, et al.
Publicado: (2023)

Intestinal homeostasis in the gut-lung-kidney axis: a prospective therapeutic target in immune-related chronic kidney diseases
por: Liu, Xinyin, et al.
Publicado: (2023)

Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease
por: Jalal, Diana, et al.
Publicado: (2018)

Weak Expression of Terminal Complement in Active Antibody-Mediated Rejection of the Kidney
por: Tiller, Gesa, et al.
Publicado: (2022)

The Complement System in Kidney Transplantation
por: Santarsiero, Donata, et al.
Publicado: (2023)

Derivation and elimination of uremic toxins from kidney-gut axis
por: Xu, Ying, et al.
Publicado: (2023)

Sustained release of hepatocyte growth factor by cationic self-assembling peptide/heparin hybrid hydrogel improves β-cell survival and function through modulating inflammatory response
por: Liu, Shuyun, et al.
Publicado: (2016)

Enteroendocrine cells and gut hormones as potential targets in the crossroad of the gut-kidney axis communication
por: Nery Neto, José Arimatéa de Oliveira, et al.
Publicado: (2023)

Enterorenal crosstalks in diabetic nephropathy and novel therapeutics targeting the gut microbiota: Gut-kidney axis in diabetic nephropathy
por: Ni, Yinhua, et al.
Publicado: (2022)

Post-transplant Alternative Complement Pathway Activation Influences Kidney Allograft Function
por: Bartoszek, Dorota, et al.
Publicado: (2019)

Complement activation and long-term graft function in ABO-incompatible kidney transplantation
por: van Sandwijk, Marit S, et al.
Publicado: (2019)

Regulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injury
por: Detsika, Maria G., et al.
Publicado: (2021)

Complement Is Activated During Normothermic Machine Perfusion of Porcine and Human Discarded Kidneys
por: Jager, Neeltina M., et al.
Publicado: (2022)

Macrophage-derived extracellular vesicles: diverse mediators of pathology and therapeutics in multiple diseases
por: Wang, Yizhuo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_8tels4p7vcqrauo1mjsclv44qe