Reduced RNA turnover as a driver of cellular senescence

Accumulation of senescent cells is an important contributor to chronic inflammation upon aging. The inflammatory phenotype of senescent cells was previously shown to be driven by cytoplasmic DNA. Here, we propose that cytoplasmic double-stranded RNA has a similar effect. We find that several cell ty...

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Detalles Bibliográficos
Autores principales: Mullani, Nowsheen, Porozhan, Yevheniia, Mangelinck, Adèle, Rachez, Christophe, Costallat, Mickael, Batsché, Eric, Goodhardt, Michele, Cenci, Giovanni, Mann, Carl, Muchardt, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812316/
https://www.ncbi.nlm.nih.gov/pubmed/33446491
http://dx.doi.org/10.26508/lsa.202000809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812316/
https://www.ncbi.nlm.nih.gov/pubmed/33446491
http://dx.doi.org/10.26508/lsa.202000809

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