Anti-oxidant MitoQ rescue of AWB chemosensory neuron impairment in a C. elegans model of X-linked Adrenoleukodystrophy

X-linked Adrenoleukodystrophy (X-ALD) is a neurometabolic disorder caused by a defective peroxisomal ABCD1 transporter of very long-chain fatty acids (VLCFAs). We have characterized a nematode model of X-ALD with loss of the pmp-4 gene, the worm orthologue of ABCD1. These mutants recapitulated the k...

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Detalles Bibliográficos
Autores principales: Guha, Sanjib, Pujol, Aurora, Dalfo, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812386/
https://www.ncbi.nlm.nih.gov/pubmed/33474532
http://dx.doi.org/10.17912/micropub.biology.000346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812386/
https://www.ncbi.nlm.nih.gov/pubmed/33474532
http://dx.doi.org/10.17912/micropub.biology.000346

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