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Mitochondrial replacement by genome transfer in human oocytes: Efficacy, concerns, and legality

BACKGROUND: Pathogenic mitochondrial (mt)DNA mutations, which often cause life‐threatening disorders, are maternally inherited via the cytoplasm of oocytes. Mitochondrial replacement therapy (MRT) is expected to prevent second‐generation transmission of mtDNA mutations. However, MRT may affect the f...

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Detalles Bibliográficos
Autores principales: Yamada, Mitsutoshi, Sato, Suguru, Ooka, Reina, Akashi, Kazuhiro, Nakamura, Akihiro, Miyado, Kenji, Akutsu, Hidenori, Tanaka, Mamoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812462/
https://www.ncbi.nlm.nih.gov/pubmed/33488283
http://dx.doi.org/10.1002/rmb2.12356