Thiophene-Pyrazolourea Derivatives as Potent, Orally Bioavailable, and Isoform-Selective JNK3 Inhibitors

[Image: see text] Potent JNK3 isoform selective inhibitors were developed from a thiophenyl-pyrazolourea scaffold. Through structure activity relationship (SAR) studies utilizing enzymatic and cell-based assays, and in vitro and in vivo drug metabolism and pharmacokinetic (DMPK) studies, potent and...

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Detalles Bibliográficos
Autores principales: Feng, Yangbo, Park, HaJeung, Bauer, Luke, Ryu, Jae Cheon, Yoon, Sung OK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812606/
https://www.ncbi.nlm.nih.gov/pubmed/33488960
http://dx.doi.org/10.1021/acsmedchemlett.0c00533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812606/
https://www.ncbi.nlm.nih.gov/pubmed/33488960
http://dx.doi.org/10.1021/acsmedchemlett.0c00533

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