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Ataluren and aminoglycosides stimulate read-through of nonsense codons by orthogonal mechanisms

During protein synthesis, nonsense mutations, resulting in premature stop codons (PSCs), produce truncated, inactive protein products. Such defective gene products give rise to many diseases, including cystic fibrosis, Duchenne muscular dystrophy (DMD), and some cancers. Small molecule nonsense supp...

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Detalles Bibliográficos
Autores principales: Ng, Martin Y., Li, Hong, Ghelfi, Mikel D., Goldman, Yale E., Cooperman, Barry S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812769/
https://www.ncbi.nlm.nih.gov/pubmed/33414181
http://dx.doi.org/10.1073/pnas.2020599118