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Ataluren and aminoglycosides stimulate read-through of nonsense codons by orthogonal mechanisms
During protein synthesis, nonsense mutations, resulting in premature stop codons (PSCs), produce truncated, inactive protein products. Such defective gene products give rise to many diseases, including cystic fibrosis, Duchenne muscular dystrophy (DMD), and some cancers. Small molecule nonsense supp...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812769/ https://www.ncbi.nlm.nih.gov/pubmed/33414181 http://dx.doi.org/10.1073/pnas.2020599118 |