Massively parallel discovery of human-specific substitutions that alter enhancer activity

Genetic changes that altered the function of gene regulatory elements have been implicated in the evolution of human traits such as the expansion of the cerebral cortex. However, identifying the particular changes that modified regulatory activity during human evolution remain challenging. Here we u...

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Detalles Bibliográficos
Autores principales: Uebbing, Severin, Gockley, Jake, Reilly, Steven K., Kocher, Acadia A., Geller, Evan, Gandotra, Neeru, Scharfe, Curt, Cotney, Justin, Noonan, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812811/
https://www.ncbi.nlm.nih.gov/pubmed/33372131
http://dx.doi.org/10.1073/pnas.2007049118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812811/
https://www.ncbi.nlm.nih.gov/pubmed/33372131
http://dx.doi.org/10.1073/pnas.2007049118

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