A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis

BACKGROUND: Glioma is sensitive to microtubule-targeting agents (MTAs), but most MTAs do not cross the blood brain barrier (BBB). To address this limitation, we developed the new chemical entity, ST-401, a brain-penetrant MTA. METHODS: Synthesis of ST-401. Measures of MT assembly and dynamics. Cell...

Descripción completa

Detalles Bibliográficos
Autores principales: Horne, Eric A, Diaz, Philippe, Cimino, Patrick J, Jung, Erik, Xu, Cong, Hamel, Ernest, Wagenbach, Michael, Kumasaka, Debra, Wageling, Nicholas B, Azorín, Daniel D, Winkler, Frank, Wordeman, Linda G, Holland, Eric C, Stella, Nephi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813200/
https://www.ncbi.nlm.nih.gov/pubmed/33506204
http://dx.doi.org/10.1093/noajnl/vdaa165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813200/
https://www.ncbi.nlm.nih.gov/pubmed/33506204
http://dx.doi.org/10.1093/noajnl/vdaa165

Ejemplares similares