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The Blockade of TACE-Dependent EGF Receptor Activation by Losartan-Erlotinib Combination Attenuates Renal Fibrosis Formation in 5/6-Nephrectomized Rats Under Vitamin D Deficiency

Chronic kidney disease (CKD) has been considered a major public health issue. In addition to cardiovascular diseases and infections, hypovitaminosis D has been considered a non-traditional aggravating factor for CKD progression. Interstitial fibrosis is a hallmark of CKD strongly correlated with det...

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Detalles Bibliográficos
Autores principales: Gonçalves, Janaína Garcia, Canale, Daniele, de Bragança, Ana Carolina, Seguro, Antonio Carlos, Shimizu, Maria Heloisa Massola, Volpini, Rildo Aparecido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813781/
https://www.ncbi.nlm.nih.gov/pubmed/33469545
http://dx.doi.org/10.3389/fmed.2020.609158