Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing

The human prototypical SR protein SRSF1 is an oncoprotein that contains two RRMs and plays a pivotal role in RNA metabolism. We determined the structure of the RRM1 bound to RNA and found that the domain binds preferentially to a CN motif (N is for any nucleotide). Based on this solution structure,...

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Detalles Bibliográficos
Autores principales: Cléry, Antoine, Krepl, Miroslav, Nguyen, Cristina K. X., Moursy, Ahmed, Jorjani, Hadi, Katsantoni, Maria, Okoniewski, Michal, Mittal, Nitish, Zavolan, Mihaela, Sponer, Jiri, Allain, Frédéric H.-T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813835/
https://www.ncbi.nlm.nih.gov/pubmed/33462199
http://dx.doi.org/10.1038/s41467-020-20481-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813835/
https://www.ncbi.nlm.nih.gov/pubmed/33462199
http://dx.doi.org/10.1038/s41467-020-20481-w

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