Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteo...

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Detalles Bibliográficos
Autores principales: Garcia-Gomez, Antonio, Li, Tianlu, de la Calle-Fabregat, Carlos, Rodríguez-Ubreva, Javier, Ciudad, Laura, Català-Moll, Francesc, Godoy-Tena, Gerard, Martín-Sánchez, Montserrat, San-Segundo, Laura, Muntión, Sandra, Morales, Xabier, Ortiz-de-Solórzano, Carlos, Oyarzabal, Julen, San José-Enériz, Edurne, Esteller, Manel, Agirre, Xabier, Prosper, Felipe, Garayoa, Mercedes, Ballestar, Esteban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813865/
https://www.ncbi.nlm.nih.gov/pubmed/33462210
http://dx.doi.org/10.1038/s41467-020-20715-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813865/
https://www.ncbi.nlm.nih.gov/pubmed/33462210
http://dx.doi.org/10.1038/s41467-020-20715-x

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