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Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner

Autophagy is a cellular degradation system contributing to homeostasis of tissue stem cells including haematopoietic stem cells (HSCs). It plays pleiotropic roles in HSC characteristics throughout life, but its stage-specific roles in HSC self-renewal are unclear. To investigate the effects of Atg5...

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Detalles Bibliográficos
Autores principales: Nomura, Naho, Ito, Chiaki, Ooshio, Takako, Tadokoro, Yuko, Kohno, Susumu, Ueno, Masaya, Kobayashi, Masahiko, Kasahara, Atsuko, Takase, Yusuke, Kurayoshi, Kenta, Si, Sha, Takahashi, Chiaki, Komatsu, Masaaki, Yanagawa, Toru, Hirao, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814027/
https://www.ncbi.nlm.nih.gov/pubmed/33462315
http://dx.doi.org/10.1038/s41598-021-81076-z