Cargando…

Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner

Autophagy is a cellular degradation system contributing to homeostasis of tissue stem cells including haematopoietic stem cells (HSCs). It plays pleiotropic roles in HSC characteristics throughout life, but its stage-specific roles in HSC self-renewal are unclear. To investigate the effects of Atg5...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nomura, Naho, Ito, Chiaki, Ooshio, Takako, Tadokoro, Yuko, Kohno, Susumu, Ueno, Masaya, Kobayashi, Masahiko, Kasahara, Atsuko, Takase, Yusuke, Kurayoshi, Kenta, Si, Sha, Takahashi, Chiaki, Komatsu, Masaaki, Yanagawa, Toru, Hirao, Atsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814027/ https://www.ncbi.nlm.nih.gov/pubmed/33462315 http://dx.doi.org/10.1038/s41598-021-81076-z

Ejemplares similares

Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas
por: Vu, Ha Thi, et al.
Publicado: (2018)

Therapeutic advantage of targeting lysosomal membrane integrity supported by lysophagy in malignant glioma
por: Jing, Yongwei, et al.
Publicado: (2022)

Pillar[6]arene acts as a biosensor for quantitative detection of a vitamin metabolite in crude biological samples
por: Ueno, Masaya, et al.
Publicado: (2020)

Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line
por: Noguchi, Masafumi, et al.
Publicado: (2023)

Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation
por: Kurayoshi, Kenta, et al.
Publicado: (2023)

Mental well‐being of staff in long‐term care facilities at risk
por: Ura, Chiaki, et al.
Publicado: (2021)

Acetate attenuates kidney fibrosis in an oxidative stress‐dependent manner
por: Kawabata, Chiaki, et al.
Publicado: (2023)

p62/SQSTM1: ‘Jack of all trades’ in health and cancer
por: Sánchez‐Martín, Pablo, et al.
Publicado: (2018)

Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression
por: Ali, Mohamed A. E., et al.
Publicado: (2017)

Tiny Drosophila makes giant strides in cancer research
por: Yamamura, Ryodai, et al.
Publicado: (2021)

The caspase-6–p62 axis modulates p62 droplets based autophagy in a dominant-negative manner
por: Valionyte, Evelina, et al.
Publicado: (2021)

p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control
por: Eskelinen, Eeva-Liisa, et al.
Publicado: (2021)

Salinity induces carbohydrate accumulation and sugar-regulated starch biosynthetic genes in tomato (Solanum lycopersicum L. cv. ‘Micro-Tom’) fruits in an ABA- and osmotic stress-independent manner
por: Yin, Yong-Gen, et al.
Publicado: (2010)

Meaning of death among care workers of geriatric institutions in a death-avoidant culture: Qualitative descriptive analyses of in-depth interviews by Buddhist priests
por: Ogawa, Yukan, et al.
Publicado: (2022)

Activation of p62/SQSTM1–Keap1–Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer
por: Ichimura, Yoshinobu, et al.
Publicado: (2018)

Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy
por: Ono, Maiko, et al.
Publicado: (2022)

Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin
por: Donohue, Elizabeth, et al.
Publicado: (2014)

Anti-Mi2 Antibody Positive Dermatomyositis With Hyper-Elevated Creatine Kinase: A Case Report
por: Ohta, Ryuichi, et al.
Publicado: (2022)

Seronegative Ocular Myasthenia Gravis in an Older Woman With Transient Dizziness and Diplopia
por: Yoshioka, Naho, et al.
Publicado: (2022)

Formation of high molecular weight p62 by CORM-3
por: Aki, Toshihiko, et al.
Publicado: (2019)

Regucalcin enhances adipocyte differentiation and attenuates inflammation in 3T3‐L1 cells
por: Murata, Tomiyasu, et al.
Publicado: (2020)

NFYA promotes malignant behavior of triple-negative breast cancer in mice through the regulation of lipid metabolism
por: Okada, Nobuhiro, et al.
Publicado: (2023)

Living Donor Liver Transplantation with Renoportal Anastomosis for a Patient with Congenital Absence of the Portal Vein
por: Uchida, Hajime, et al.
Publicado: (2012)

Cysteinyl leukotriene receptor antagonist regulates allergic airway inflammation in an organ- and cytokine-specific manner
por: Kawano, Tetsuya, et al.
Publicado: (2014)

Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62‐dependent manner
por: Han, Da, et al.
Publicado: (2021)

Recapitulative haematopoietic development of human pluripotent stem cells in the absence of exogenous haematopoietic cytokines
por: Philonenko, Elena S., et al.
Publicado: (2021)

The Role of Nutrients in Maintaining Hematopoietic Stem Cells and Healthy Hematopoiesis for Life
por: Tadokoro, Yuko, et al.
Publicado: (2022)

Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant
por: Kageyama, Shun, et al.
Publicado: (2018)

Cocktail δ-integration: a novel method to construct cellulolytic enzyme expression ratio-optimized yeast strains
por: Yamada, Ryosuke, et al.
Publicado: (2010)

Direct ethanol production from cellulosic materials using a diploid strain of Saccharomyces cerevisiae with optimized cellulase expression
por: Yamada, Ryosuke, et al.
Publicado: (2011)

Autoimmune Vasculitis Causing Acute Bilateral Lower Limb Paralysis
por: Tokonami, Ayuko, et al.
Publicado: (2022)

Changes in the Comprehensiveness of Rural Medical Care for Older Japanese Patients during the COVID-19 Pandemic
por: Ohta, Ryuichi, et al.
Publicado: (2021)

The WHO's who of haematopoietic malignancies
por: Oram, S H, et al.
Publicado: (2009)

Regucalcin confers resistance to amyloid‐β toxicity in neuronally differentiated PC12 cells
por: Murata, Tomiyasu, et al.
Publicado: (2018)

Targeting RB1 Loss in Cancers
por: Linn, Paing, et al.
Publicado: (2021)

The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour
por: Lilly, Andrew J., et al.
Publicado: (2011)

BRAF V600 mutations in Langerhans cell histiocytosis with a simple and unique assay
por: Tatsuno, Michiko, et al.
Publicado: (2016)

Autophagic-Lysosomal Inhibition Compromises Ubiquitin-Proteasome System Performance in a p62 Dependent Manner in Cardiomyocytes
por: Tian, Zongwen, et al.
Publicado: (2014)

In vivo biodistribution analysis of transmission competent and defective RNA virus-based episomal vector
por: Komatsu, Yumiko, et al.
Publicado: (2020)

Motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat
por: Karube, Fuyuki, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_864tjc215pbob4pc6aajsqctdr