Pan RAS-binding compounds selected from a chemical library by inhibiting interaction between RAS and a reduced affinity intracellular antibody

Intracellular antibodies are valuable tools for target validation studies for clinical situations such as cancer. Recently we have shown that antibodies can be used for drug discovery in screening for chemical compounds surrogates by showing that compounds could be developed to the so-called undrugg...

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Detalles Bibliográficos
Autores principales: Tanaka, Tomoyuki, Thomas, Jemima, Van Montfort, Rob, Miller, Ami, Rabbitts, Terry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814043/
https://www.ncbi.nlm.nih.gov/pubmed/33462327
http://dx.doi.org/10.1038/s41598-021-81262-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814043/
https://www.ncbi.nlm.nih.gov/pubmed/33462327
http://dx.doi.org/10.1038/s41598-021-81262-z

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