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Developing T cells form an immunological synapse for passage through the β-selection checkpoint

The β-selection checkpoint of T cell development tests whether the cell has recombined its genomic DNA to produce a functional T cell receptor β (TCRβ). Passage through the β-selection checkpoint requires the nascent TCRβ protein to mediate signaling through a pre-TCR complex. In this study, we show...

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Detalles Bibliográficos
Autores principales: Allam, Amr H., Charnley, Mirren, Pham, Kim, Russell, Sarah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814350/
https://www.ncbi.nlm.nih.gov/pubmed/33464309
http://dx.doi.org/10.1083/jcb.201908108