Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex

Adaptor protein complex 5 (AP-5) and its partners, SPG11 and SPG15, are recruited onto late endosomes and lysosomes. Here we show that recruitment of AP-5/SPG11/SPG15 is enhanced in starved cells and occurs by coincidence detection, requiring both phosphatidylinositol 3-phosphate (PI3P) and Rag GTPa...

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Detalles Bibliográficos
Autores principales: Hirst, Jennifer, Hesketh, Geoffrey G., Gingras, Anne-Claude, Robinson, Margaret S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814351/
https://www.ncbi.nlm.nih.gov/pubmed/33464297
http://dx.doi.org/10.1083/jcb.202002075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814351/
https://www.ncbi.nlm.nih.gov/pubmed/33464297
http://dx.doi.org/10.1083/jcb.202002075

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