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Jo-1 autoantigen-specific B cells are skewed towards distinct functional B cell subsets in anti-synthetase syndrome patients

BACKGROUND: Anti-Jo-1 autoantibodies which recognize histidyl-tRNA synthetase identify patients with the rare rheumatologic disease, anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS), a phenotypically distinct subset of idiopathic inflammatory myopathies (IIM). Jo-1-binding B cells (JBCs) are implic...

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Detalles Bibliográficos
Autores principales: Young-Glazer, Jennifer, Cisneros, Alberto, Wilfong, Erin M., Smith, Scott A., Crofford, Leslie J., Bonami, Rachel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814460/
https://www.ncbi.nlm.nih.gov/pubmed/33468230
http://dx.doi.org/10.1186/s13075-020-02412-8