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Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson’s disease
BACKGROUND: Microglia activation induced by α-synuclein (α-syn) is one of the most important factors in Parkinson’s disease (PD) pathogenesis. However, the molecular mechanisms by which α-syn exerts neuroinflammation and neurotoxicity remain largely elusive. Targeting metabotropic glutamate receptor...
Autores principales: | Zhang, Ya-Nan, Fan, Jing-Kai, Gu, Li, Yang, Hui-Min, Zhan, Shu-Qin, Zhang, Hong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814625/ https://www.ncbi.nlm.nih.gov/pubmed/33461598 http://dx.doi.org/10.1186/s12974-021-02079-1 |
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